How Acetaminophen works on Arthritis:
Acetaminophen a.k.a N-acetyl-p-aminophenol (APAP) belongs to a drug class known as analgesics (pain reliever) and antipyretics (fever reducer). Acetaminohen does not reduce the inflammation associated with arthritis. The exact mechanism how acetaminophen works is still unknown. It is thought that acetaminophen reduces pain by increasing the “threshold of pain”, which means that it would require large amounts of pain to be developed before a person taking this drug can feel it.
Side Effects and Precautions of Acetaminophen:
Hepatotoxicity is associated with acetaminophen overdose. Smoking may interfere with the effectiveness of this medication and smokers may need higher dose. Long term use of Acetaminophen may decrease the kidney function. The most common side effect with acetaminophen is lightheadedness. Acetaminophen is well tolerated and safer to use compared to traditional NSAIDs.
Forms, Dosage and Brand Names of Acetaminophen:
Sudafed®, Theraflu®, and Tylenol® Maximum dosage
Adults: 4,000 mg per day.
Pregnant women:- Acetaminophen has not been reported to cause birth defects or other complications. Consult your doctor for proper dosage.
Children: Dose must be determined by the doctor
References about Acetaminophen and Arthritis:
Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, Moskowitz RW, Schnitzer TJ. Guidelines for the medical management of osteoarthritis. Part I. Osteoarthritis of the hip.American College of Rheumatology. Arthritis Rheum. 1995 Nov;38(11):1535–1540.
Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, Moskowitz RW, Schnitzer TJ. Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee.American College of Rheumatology. Arthritis Rheum. 1995 Nov;38(11):1541–1546.
Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000 Sep;43(9):1905–1915.